https://doi.org/10.1038/s41586-023-05729-x · 
Видання: Nature, 2023, №7957, с.534-542
Видавець: Springer Science and Business Media LLC
Автори:
- Maise Al Bakir
- Ariana Huebner
- Carlos Martínez-Ruiz
- Kristiana Grigoriadis
- Thomas B. K. Watkins
- Oriol Pich
- David A. Moore
- Selvaraju Veeriah
- Sophia Ward
- Joanne Laycock
- Diana Johnson
- Andrew Rowan
- Maryam Razaq
- Mita Akther
- Cristina Naceur-Lombardelli
- Paulina Prymas
- Antonia Toncheva
- Sonya Hessey
- Michelle Dietzen
- Emma Colliver
- Alexander M. Frankell
- Abigail Bunkum
- Emilia L. Lim
- Takahiro Karasaki
- Christopher Abbosh
- Crispin T. Hiley
- Mark S. Hill
- Daniel E. Cook
- Gareth A. Wilson
- Roberto Salgado
- Emma Nye
- Richard Kevin Stone
- Dean A. Fennell
- Gillian Price
- Keith M. Kerr
- Babu Naidu
- Gary Middleton
- Yvonne Summers
- Colin R. Lindsay
- Fiona H. Blackhall
- Judith Cave
- Kevin G. Blyth
- Arjun Nair
- Asia Ahmed
- Magali N. Taylor
- Alexander James Procter
- Mary Falzon
- David Lawrence
- Neal Navani
- Ricky M. Thakrar
- Sam M. Janes
- Dionysis Papadatos-Pastos
- Martin D. Forster
- Siow Ming Lee
- Tanya Ahmad
- Sergio A. Quezada
- Karl S. Peggs
- Peter Van Loo
- Caroline Dive
- Allan Hackshaw
- Nicolai J. Birkbak
- Simone Zaccaria
- Jason F. Lester
- Amrita Bajaj
- Apostolos Nakas
- Azmina Sodha-Ramdeen
- Keng Ang
- Mohamad Tufail
- Mohammed Fiyaz Chowdhry
- Molly Scotland
- Rebecca Boyles
- Sridhar Rathinam
- Claire Wilson
- Domenic Marrone
- Sean Dulloo
- Gurdeep Matharu
- Jacqui A. Shaw
- Joan Riley
- Lindsay Primrose
- Ekaterini Boleti
- Heather Cheyne
- Mohammed Khalil
- Shirley Richardson
- Tracey Cruickshank
- Sarah Benafif
- Kayleigh Gilbert
- Akshay J. Patel
- Aya Osman
- Christer Lacson
- Gerald Langman
- Helen Shackleford
- Madava Djearaman
- Salma Kadiri
- Angela Leek
- Jack Davies Hodgkinson
- Nicola Totten
- Angeles Montero
- Elaine Smith
- Eustace Fontaine
- Felice Granato
- Helen Doran
- Juliette Novasio
- Kendadai Rammohan
- Leena Joseph
- Paul Bishop
- Rajesh Shah
- Stuart Moss
- Vijay Joshi
- Philip Crosbie
- Fabio Gomes
- Kate Brown
- Mathew Carter
- Anshuman Chaturvedi
- Lynsey Priest
- Pedro Oliveira
- Matthew G. Krebs
- Alexandra Clipson
- Jonathan Tugwood
- Alastair Kerr
- Dominic G. Rothwell
- Elaine Kilgour
- Hugo J. W. L. Aerts
- Roland F. Schwarz
- Tom L. Kaufmann
- Rachel Rosenthal
- Zoltan Szallasi
- Judit Kisistok
- Mateo Sokac
- Miklos Diossy
- Jonas Demeulemeester
- Aengus Stewart
- Alastair Magness
- Angeliki Karamani
- Benny Chain
- Brittany B. Campbell
- Carla Castignani
- Chris Bailey
- Clare Puttick
- Clare E. Weeden
- Claudia Lee
- Corentin Richard
- David R. Pearce
- Despoina Karagianni
- Dhruva Biswas
- Dina Levi
- Elena Hoxha
- Elizabeth Larose Cadieux
- Eva Grönroos
- Felip Gálvez-Cancino
- Foteini Athanasopoulou
- Francisco Gimeno-Valiente
- George Kassiotis
- Georgia Stavrou
- Gerasimos Mastrokalos
- Haoran Zhai
- Helen L. Lowe
- Ignacio Matos
- Jacki Goldman
- James L. Reading
- James R. M. Black
- Javier Herrero
- Jayant K. Rane
- Jerome Nicod
- Jie Min Lam
- John A. Hartley
- Katey S. S. Enfield
- Kayalvizhi Selvaraju
- Kerstin Thol
- Kevin Litchfield
- Kevin W. Ng
- Kezhong Chen
- Krijn Dijkstra
- Krupa Thakkar
- Leah Ensell
- Mansi Shah
- Marcos Vasquez
- Maria Litovchenko
- Mariana Werner Sunderland
- Michelle Leung
- Mickael Escudero
- Mihaela Angelova
- Miljana Tanić
- Monica Sivakumar
- Nnennaya Kanu
- Olga Chervova
- Olivia Lucas
- Othman Al-Sawaf
- Philip Hobson
- Piotr Pawlik
- Robert Bentham
- Robert E. Hynds
- Roberto Vendramin
- Sadegh Saghafinia
- Saioa López
- Samuel Gamble
- Seng Kuong Anakin Ung
- Sharon Vanloo
- Stefan Boeing
- Stephan Beck
- Supreet Kaur Bola
- Tamara Denner
- Teresa Marafioti
- Thanos P. Mourikis
- Victoria Spanswick
- Vittorio Barbè
- Wei-Ting Lu
- William Hill
- Wing Kin Liu
- Yin Wu
- Yutaka Naito
- Zoe Ramsden
- Catarina Veiga
- Gary Royle
- Charles-Antoine Collins-Fekete
- Francesco Fraioli
- Paul Ashford
- Tristan Clark
- Elaine Borg
- James Wilson
- Davide Patrini
- Emilie Martinoni Hoogenboom
- Fleur Monk
- James W. Holding
- Junaid Choudhary
- Kunal Bhakhri
- Marco Scarci
- Martin Hayward
- Nikolaos Panagiotopoulos
- Pat Gorman
- Reena Khiroya
- Robert C. M. Stephens
- Yien Ning Sophia Wong
- Steve Bandula
- Abigail Sharp
- Sean Smith
- Nicole Gower
- Harjot Kaur Dhanda
- Kitty Chan
- Camilla Pilotti
- Rachel Leslie
- Anca Grapa
- Hanyun Zhang
- Khalid AbdulJabbar
- Xiaoxi Pan
- Yinyin Yuan
- David Chuter
- Mairead MacKenzie
- Serena Chee
- Aiman Alzetani
- Lydia Scarlett
- Jennifer Richards
- Papawadee Ingram
- Silvia Austin
- Eric Lim
- Paulo De Sousa
- Simon Jordan
- Alexandra Rice
- Hilgardt Raubenheimer
- Harshil Bhayani
- Lyn Ambrose
- Anand Devaraj
- Hema Chavan
- Sofina Begum
- Silviu I. Buderi
- Daniel Kaniu
- Mpho Malima
- Sarah Booth
- Andrew G. Nicholson
- Nadia Fernandes
- Pratibha Shah
- Chiara Proli
- Madeleine Hewish
- Sarah Danson
- Michael J. Shackcloth
- Lily Robinson
- Peter Russell
- Craig Dick
- John Le Quesne
- Alan Kirk
- Mo Asif
- Rocco Bilancia
- Nikos Kostoulas
- Mathew Thomas
- Mariam Jamal-Hanjani
- Nicholas McGranahan
- Charles Swanton
- TRACERx Consortium
Анотація
AbstractMetastatic disease is responsible for the majority of cancer-related deaths1. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of 144 non-metastatic tumours. In 25% of cases, metastases diverged early, before the last clonal sweep in the primary tumour, and early divergence was enriched for patients who were smokers at the time of initial diagnosis. Simulations suggested that early metastatic divergence more frequently occurred at smaller tumour diameters (less than 8 mm). Single-region primary tumour sampling resulted in 83% of late divergence cases being misclassified as early, highlighting the importance of extensive primary tumour sampling. Polyclonal dissemination, which was associated with extrathoracic disease recurrence, was found in 32% of cases. Primary lymph node disease contributed to metastatic relapse in less than 20% of cases, representing a hallmark of metastatic potential rather than a route to subsequent recurrences/disease progression. Metastasis-seeding subclones exhibited subclonal expansions within primary tumours, probably reflecting positive selection. Our findings highlight the importance of selection in metastatic clone evolution within untreated primary tumours, the distinction between monoclonal versus polyclonal seeding in dictating site of recurrence, the limitations of current radiological screening approaches for early diverging tumours and the need to develop strategies to target metastasis-seeding subclones before relapse.
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